A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long Term Side Effects after Finasteride Discontinuation
Cecchin et al., 2014
“Our explorative study tried to shed a light on such phenomenon as well as to highlight a possible genetic predisposition to the development of such disabling chronic side effects that can deeply impact the quality of life of young men assuming finasteride to treat alopecia.”
A significantly higher occurrence of “extreme length” androgen receptor polymorphisms (CAG-rs4045402 and GGN-rs3138869) was observed in 69 PFS patients as compared to controls (without male pattern hair loss). This finding was suggestive of a potential genetic role in the development of both male pattern baldness and Post-Finasteride Syndrome.
The authors suggest the role of epigenetic proteins and their regulation could play a role in the regulation of AR expression after finasteride discontinuation and the development of chronic side effects.
